Gallbladder carriage generates genetic variation and genome degradation in Salmonella Typhi.

ABSTRACT: Despite recent advances in typhoid fever control, asymptomatic carriage of Salmonella Typhi in the gallbladder remains poorly understood. Aiming to understand if S. Typhi becomes genetically adapted for long-term colonisation in the gallbladder, we performed whole genome sequencing on a collection of S. Typhi isolated from the gallbladders of typhoid carriers. These sequences were compared to contemporaneously sampled sequences from organisms isolated from the blood of acute patients within the same population. We found that S. Typhi carriage was not restricted to any particular genotype or conformation of antimicrobial resistance genes, but was largely reflective of S. Typhi circulating in the general population. However, gallbladder isolates showed a higher genetic variability than acute

SUBMITTER: Thanh Duy P 

PROVIDER: S-EPMC7605710 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature