Alternative dosing guidelines to improve outcomes in childhood tuberculosis: a mathematical modelling study.

ABSTRACT:

Background

Malnourished and young children are particularly susceptible to severe forms of tuberculosis and poor treatment response. WHO dosing guidelines for drugs for tuberculosis treatment are based only on weight, which might lead to systematic underdosing and poor outcomes in these children. We aimed to assess and quantify the population effect of WHO guidelines for drug-susceptible tuberculosis in children in the 20 countries with the highest disease burden.

Methods

We used an integrated model that linked country-specific demographic data at the individual level from the 20 countries with the highest disease burden to pharmacokinetic, outcome, and epidemiological models. We estimated tuberculosis treatment outcomes in children younger than 5 years following WHO guideli

SUBMITTER: Radtke KK 

PROVIDER: S-EPMC7605863 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature