Susceptibility of PON1/PON2 Genetic Variations to Ischemic Stroke Risk in a Chinese Han Population.

ABSTRACT:

Background

Paraoxonases (PONs) are a family of orphan enzymes with multiple functions, including anti-inflammatory, antioxidative, antiatherogenic activities. Studies have suggested that genetic variations in PON1 and PON2 are associated with ischemic stroke (IS) risk; however, the conclusion remains unclear in the Chinese population.

Methods

To investigate the susceptibility of genetic variations in PON1 and PON2 to risk of IS and its subtypes, this case-control study was carried out on a Chinese population comprising 300 IS patients and 300 healthy controls. Genotypes of six genetic variations in PON1 and PON2 were identified with an improved multiplex ligase detection-reaction technique.

Results

PON1 rs662 was associ

SUBMITTER: Pan Y 

PROVIDER: S-EPMC7605958 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature