Aspirin overcomes cisplatin resistance in lung cancer by inhibiting cancer cell stemness.

ABSTRACT:

Background

Lung cancer is the leading cause of cancer death and is commonly treated by cisplatin. Although cisplatin treatment may initially be successful, its effectiveness usually reduces significantly in disease-recurrent patients. Aspirin, a nonselective COX inhibitor, has been shown to help reverse the status of cisplatin sensitivity in recurrent human ovarian cancer cells. This study aimed to explore the effect of aspirin on cisplatin resistance through the perspective of cancer cell stemness.

Methods

We used clustering analysis to predict the H460 cisplatin resistance from the GSE21656 dataset. The increased lung cancer cell stemness may contribute to enhanced tolerance. In this study, we used aspirin, a nonselective COX inhibitor, with cisplatin for several hours in

SUBMITTER: Zhao M 

PROVIDER: S-EPMC7605995 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature