Culinary spice bioactives as potential therapeutics against SARS-CoV-2: Computational investigation.

ABSTRACT:

Background

Coronavirus disease-2019 (COVID-19) is an infectious pandemic caused by SARS-CoV-2. SARS-CoV-2 main protease (M^pro) and spike protein are crucial for viral replication and transmission. Spike protein recognizes the human ACE2 receptor and transmits SARS-CoV-2 into the human body. Thus, M^pro, spike protein, and ACE2 receptor act as appropriate targets for the development of therapeutics against SARS-CoV-2. Spices are traditionally known to have anti-viral and immune-boosting activities. Therefore, we investigated the possible use of selected spice bioactives against the potential targets of SARS-CoV-2 using computational analysis.

Methods

Molecular docking analysis was performed to analyze the binding efficiency of spice bioactives against SAR

SUBMITTER: Natesh J 

PROVIDER: S-EPMC7606080 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature