Modulation of protein fate decision by small molecules: targeting molecular chaperone machinery.

ABSTRACT: Modulation of protein fate decision and protein homeostasis plays a significant role in altering the protein level, which acts as an orientation to develop drugs with new mechanisms. The molecular chaperones exert significant biological functions on modulation of protein fate decision and protein homeostasis under constantly changing environmental conditions through extensive protein-protein interactions (PPIs) with their client proteins. With the help of molecular chaperone machinery, the processes of protein folding, trafficking, quality control and degradation of client proteins could be arranged properly. The core members of molecular chaperones, including heat shock proteins (HSPs) family and their co-chaperones, are emerging as potential drug targets since they are involved in numero

SUBMITTER: Wang L 

PROVIDER: S-EPMC7606112 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature