A modeling informed quantitative approach to salvage clinical trials interrupted due to COVID-19.

ABSTRACT: Many ongoing Alzheimer's disease central nervous system clinical trials are being disrupted and halted due to the COVID-19 pandemic. They are often of a long duration' are very complex; and involve many stakeholders, not only the scientists and regulators but also the patients and their family members. It is mandatory for us as a community to explore all possibilities to avoid losing all the knowledge we have gained from these ongoing trials. Some of these trials will need to completely restart, but a substantial number can restart after a hiatus with the proper protocol amendments. To salvage the information gathered so far, we need out-of-the-box thinking for addressing these missingness problems and to combine information from the completers with those subjects undergoing complex protoc

SUBMITTER: Geerts H 

PROVIDER: S-EPMC7606183 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature