Associations of α- and γ-tocopherol during early life with lung function in childhood.

ABSTRACT:

Background

Tocopherol isoforms may regulate child lung growth and spirometric measures.

Objective

Our aim was to determine the extent to which plasma α-tocopherol (α-T) or γ-tocopherol (γ-T) isoform levels in early childhood or in utero are associated with childhood lung function.

Methods

We included 622 participants in the Project Viva cohort who had lung function at a mid-childhood visit (age 6-10 years). Maternal and child tocopherol isoform levels were measured by HPLC at the second trimester and 3 years of age, respectively. Multivariable linear regression models (adjusted for mid-childhood body mass index z scores, maternal education, smoking in pregnancy, and prenatal particulate matter with diameter of <2.5 micrometers (PM_2.5) particulate exposure)

SUBMITTER: Kumar R 

PROVIDER: S-EPMC7606217 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature