Persistent negative symptoms in youth at clinical high risk for psychosis: A longitudinal study.

ABSTRACT:

Background

Severity of negative symptoms has been associated with poor functioning, cognitive deficits, and defeatist beliefs in schizophrenia patients. However, one area that remains understudied is persistent negative symptoms (PNS). Negative symptoms, including PNS, have been observed in those at clinical high-risk (CHR) for psychosis. The aim of this study was to determine if PNS were associated with functioning, neurocognition, and defeatist beliefs in a CHR sample.

Method

CHR participants (n = 764) were recruited for the North American Prodrome Longitudinal Study. Negative symptoms were rated on the Scale of Psychosis-risk Symptoms. Generalized linear mixed models for repeated measures were used to examine changes over time between and within groups (PNS vs non-PNS).

SUBMITTER: Devoe DJ 

PROVIDER: S-EPMC7606256 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature