Assessment of Brain Glucose Metabolism Following Cardiac Arrest by [¹⁸F]FDG Positron Emission Tomography.

ABSTRACT:

Background

Cardiac arrest (CA) patients who survived by cardiopulmonary resuscitation (CPR) can present different levels of neurological deficits ranging from minor cognitive impairments to persistent vegetative state and brain death. The pathophysiology of the resulting brain injury is poorly understood, and whether changes in post-CA brain metabolism contribute to the injury are unknown. Here we utilized [¹⁸F]fluorodeoxyglucose (FDG)-Positron emission tomography (PET) to study in vivo cerebral glucose metabolism 72 h following CA in a murine CA model.

Methods

Anesthetized and ventilated adult C57BL/6 mice underwent 12-min KCl-induced CA followed by CPR. Seventy-two hours following CA, surviving mice were intraperitoneally injected with [¹⁸F]FDG (~ 186

SUBMITTER: Zhang HJ 

PROVIDER: S-EPMC7606281 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature