Activation of the 15-lipoxygenase pathway in aspirin-exacerbated respiratory disease.

ABSTRACT:

Background

Aspirin-exacerbated respiratory disease (AERD) is characterized by asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), and an intolerance of medications that inhibit cyclooxygenase-1. Patients with AERD have more severe upper and lower respiratory tract disease than do aspirin-tolerant patients with CRSwNP. A dysregulation in arachidonic acid metabolism is thought to contribute to the enhanced sinonasal inflammation in AERD.

Objective

Our aim was to utilize an unbiased approach investigating arachidonic acid metabolic pathways in AERD.

Methods

Single-cell RNA sequencing (10× Genomics, Pleasanton, Calif) was utilized to compare the transcriptional profile of nasal polyp (NP) cells from patients with AERD and patients with CRSwNP and map differences in

SUBMITTER: Stevens WW 

PROVIDER: S-EPMC7606335 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature