Strategies to reduce the risk of platinum containing antineoplastic drug-induced ototoxicity.

ABSTRACT:

Introduction

Cisplatin is a highly effective chemotherapeutic agent against a variety of solid tumors in adults and in children. Unfortunately, a large percentage of patients suffer permanent sensorineural hearing loss. Up to 60% of children and at least 50% of adults suffer this complication that seriously compromises their quality of life. Hearing loss is due to damage to the sensory cells in the inner ear. The mechanisms of cochlear damage are still being investigated. However, it appears that inner ear damage is triggered by reactive oxygen species (ROS) formation and inflammation 34.

Areas covered

We discuss a number of potential therapeutic targets that can be addressed to provide hearing protection. These strategies include enhancing the endogenous antioxidant pathway

SUBMITTER: Mukherjea D 

PROVIDER: S-EPMC7606369 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature