Prevalence and predictors of bone health among perinatally HIV-infected adolescents.

ABSTRACT:

Objectives

Long-term complications of HIV including low bone mineral density remain a concern. We studied the prevalence and predictors of low bone mineral density among South African perinatally HIV-infected adolescents (PHIVA) on antiretroviral therapy (ART).

Design

Cross-sectional analysis.

Methods

Bone health was evaluated by measuring the calcaneus stiffness index among PHIVA on ART. Low stiffness index was defined as z-score less than -2 SD compared with age-matched and sex-matched HIV-uninfected adolescents (HIV-).

Result

Overall, 407 PHIVA (median age: 14 years; 50.4% female; median age at ART initiation: 4.2 years) and 92 HIV- (median age: 13.7 years; 54.4% female) were included. Median duration on ART was 9.8 years (interquartile range 6.8-11.5) with

SUBMITTER: Mahtab S 

PROVIDER: S-EPMC7606491 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature