Sex-specific differences in rim appearance of multiple sclerosis lesions on quantitative susceptibility mapping.

ABSTRACT:

Background

Susceptibility MRI techniques, such as phase and quantitative susceptibility mapping (QSM) reveal lesion heterogeneity in MS, including the presence of lesions with outer rims suggestive of iron accumulation in macrophages and microglia, indicative of chronic-active inflammatory white matter lesions (WMLs).

Objective

To evaluate the in vivo relationship between chronic-active WMLs (as visualized by rimmed lesions on QSM) and several clinical metrics.

Methods

39 patients (15 men, 24 women) with MS underwent 7 Tesla brain MRIs and clinical evaluation. Contrast patterns of lesions identified on FLAIR and quantitative susceptibility maps were reviewed and compared to demographic characteristics and disability scores.

Results

1279 lesions were identified

SUBMITTER: B T 

PROVIDER: S-EPMC7606497 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature