Substantial decline in heavily treated therapy-experienced persons with HIV with limited antiretroviral treatment options.

ABSTRACT:

Objective

Historically, a high burden of resistance to antiretroviral therapy (ART) in heavily treatment-experienced (HTE) persons with HIV (PWH) resulted in limited treatment options (LTOs). We evaluated the prevalence, risk factors, and virologic control of HTE PWH with LTO throughout the modern ART era.

Design

We examined all ART-experienced PWH in care between 2000 and 2017 in the Centers for AIDS Research Network of Integrated Clinical Systems cohort.

Methods

We computed the annual prevalence of HTE PWH with LTO defined as having two or less available classes with two or less active drugs per class based on genotypic data and cumulative antiretroviral resistance. We used multivariable Cox proportional hazards models to examine risk of LTO by 3-year study entry pe

SUBMITTER: Bajema KL 

PROVIDER: S-EPMC7606534 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature