Mast Cell Promotes the Development of Intracranial Aneurysm Rupture.

ABSTRACT:

Background and purpose

Inflammation has emerged as a key component of the pathophysiology of intracranial aneurysms. Mast cells have been detected in human intracranial aneurysm tissues, and their presence was associated with intramural microhemorrhage and wall degeneration. We hypothesized that mast cells play a critical role in the development of aneurysmal rupture, and that mast cells can be used as a therapeutic target for the prevention of aneurysm rupture.

Methods

Intracranial aneurysms were induced in adult mice using a combination of induced systemic hypertension and a single injection of elastase into the cerebrospinal fluid. Aneurysm formation and rupture were assessed over 3 weeks. Roles of mast cells were assessed using a mast cell stabilizer (cromolyn), a mast c

SUBMITTER: Furukawa H 

PROVIDER: S-EPMC7606717 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature