Skin tape proteomics identifies pathways associated with transepidermal water loss and allergen polysensitization in atopic dermatitis.

ABSTRACT:

Background

Atopic dermatitis (AD) and food allergy (FA) are associated with skin barrier dysfunction.

Objective

Skin biomarkers are needed for skin barrier interventions studies.

Methods

In this study, skin tape strip (STS) samples were collected from nonlesional skin of 62 children in AD FA+, AD FA-, and nonatopic groups for mass spectrometry proteomic analysis. transepidermal water loss and allergic sensitization were assessed. STS proteomic analysis results were validated in an independent cohort of 41 adults with AD with and without FA versus nonatopic controls.

Results

A group of 45 proteins was identified as a principal component 1 (PC1) with the highest expression in AD FA+ STSs. This novel set of STS proteins was highly correlative to skin transepiderma

SUBMITTER: Goleva E 

PROVIDER: S-EPMC7606732 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature