The Sca-1⁺ and Sca-1^- mouse prostatic luminal cell lineages are independently sustained.

ABSTRACT: The phenotypic and functional heterogeneity of the mouse prostate epithelial cell lineages remains incompletely characterized. We show that the Sca-1⁺ luminal cells at the mouse proximal prostate express Sox2. These cells are replicative quiescent, castration resistant, and do not possess secretory function. We use the Probasin-CreER^T2 and Sox2-CreER^T2 models in concert with a fluorescent reporter line to label the Sca-1^- and Sca-1⁺ luminal cells, respectively. By a lineage tracing approach, we show that the two luminal cell populations are independently sustained. Sox2 is dispensable for the maintenance of the Sca-1⁺ luminal cells but is essential for their facultative bipotent differentiation capacity. The Sca-1⁺

SUBMITTER: Kwon OJ 

PROVIDER: S-EPMC7606766 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature