Pharmacogenetic factors affecting β-blocker metabolism and response.

ABSTRACT:

Introduction

β-blockers are among the most widely prescribed of all drugs, used for treatment of a large number of cardiovascular diseases. Herein we evaluate literature pertaining to pharmacogenetics of β-blocker therapy, provide insight into the robustness of the genetic associations, and determine the appropriateness for translating these genetic associations into clinical practice.

Areas covered

A literature search was conducted using PubMed to collate evidence on associations between CYP2D6, ADRB1, ADRB2, and GRK5 genetic variation and drug-response outcomes in the presence of β-blocker exposure. Pharmacokinetic, pharmacodynamic, and clinical outcomes studies were included if genotype data and β-blocker exposure were documented.

Expert opinion

Subst

SUBMITTER: Thomas CD 

PROVIDER: S-EPMC7606773 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature