Autoantigen Tetramer Silences Autoreactive B Cell Populations.

ABSTRACT: Many autoimmune therapies focus on immune suppression to reduce symptom severity and halt disease progression; however, currently approved treatments lack specificity for the autoantigen and rely on more global immune suppression. Multivalent antigen arrays can disarm pathogenic autoimmune B cell populations that specifically recognize the antigen of interest via their B cell receptor (BCR). Disarmament may be achieved by BCR engagement, cross-linking, and sustained receptor occupancy as a result of multivalent, high avidity BCR binding. To engage and explore this mechanism, a tetramer display of the encephalogenic proteolipid peptide (PLP_139-151), referred to as 4-arm PLP_139-151, was synthesized by copper-catalyzed azide-alkyne cycloaddition chemistry. Subcutaneous a

SUBMITTER: Christopher MA 

PROVIDER: S-EPMC7606775 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature