Spatial encoding in dorsomedial prefrontal cortex and hippocampus is related during deliberation.

ABSTRACT: Deliberation is thought to involve the internal simulation of the outcomes of candidate actions, the valuation of those outcomes, and the selection of the actions with the highest expected value. While it is known that deliberation involves prefrontal cortical areas, specifically the dorsomedial prefrontal cortex (dmPFC), as well as the hippocampus (HPC) and other brain regions, how these areas process prospective information and select actions is not well understood. We recorded simultaneously from ensembles in dmPFC and CA1 of dorsal HPC in rats during performance of a spatial contingency switching task, and examined the relationships between spatial and reward encoding in these two areas during deliberation at the choice point. We found that CA1 and dmPFC represented either goal locatio

SUBMITTER: Hasz BM 

PROVIDER: S-EPMC7606780 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature