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Enantioselective S-H Insertion Reactions of α-Carbonyl Sulfoxonium Ylides.

ABSTRACT: The first example of enantioselective S-H insertion reactions of sulfoxonium ylides is reported. Under the influence of thiourea catalysis, excellent levels of enantiocontrol (up to 95 % ee) and yields (up to 97 %) are achieved for 31 examples in S-H insertion reactions of aryl thiols and α-carbonyl sulfoxonium ylides.

SUBMITTER: Momo PB

PROVIDER: S-EPMC7606806 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Enantioselective S-H Insertion Reactions of α-Carbonyl Sulfoxonium Ylides.

Momo Patrícia B PB Leveille Alexandria N AN Farrar Elliot H E EHE Grayson Matthew N MN Mattson Anita E AE Burtoloso Antonio C B ACB

Angewandte Chemie (International ed. in English) 20200528 36

The first example of enantioselective S-H insertion reactions of sulfoxonium ylides is reported. Under the influence of thiourea catalysis, excellent levels of enantiocontrol (up to 95 % ee) and yields (up to 97 %) are achieved for 31 examples in S-H insertion reactions of aryl thiols and α-carbonyl sulfoxonium ylides. ...[more]

PMID: 32352184

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