Dysfunction of the NAc-mPFC circuit in insomnia disorder.

ABSTRACT:

Background

Insomnia disorder (ID) is a prevalent sleep disorder, which seriously affects people's daily life and was found to be associated with increased frequency of sleep stage shifts. Previous findings had revealed the critical role of the nucleus accumbens (NAc) in sleep-wake transition. However, the neuroimaging studies of the NAc in patients with ID have been rare. We hypothesized that structural and functional abnormalities of the NAc would be implicated in ID.

Methods

Twenty-six ID patients and 36 matched healthy controls (HC) were included in the current study. The volumes and corresponding resting-state functional connectivity (RSFC) of the bilateral NAc were compared between the two groups. The abnormal RSFC in ID were then correlated with Pittsburgh Sleep Qualit

SUBMITTER: Shao Z 

PROVIDER: S-EPMC7606871 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature