Sex Differences in the Sustained Effects of Ketamine on Resilience to Chronic Stress.

ABSTRACT: Exposure to stress is recognized to be a triggering factor in several mood disorders, including depression and anxiety. There is very little understanding of why female subjects have a significantly higher risk for these conditions than males. Recent findings in male rodents indicated that prophylactic ketamine can prevent the development of a stress-induced depressive-like phenotype, providing a pharmacological tool to study the mechanisms underlying stress resilience. Unfortunately, none of these studies incorporated female subjects, nor did they provide a mechanistic understanding of the effects of ketamine on stress resilience. Our previous work identified the prefrontal glutamatergic and parvalbumin (PV) systems as potential molecular mechanisms underlying sex differences in susceptib

SUBMITTER: Okine T 

PROVIDER: S-EPMC7606988 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature