TP53 mutation and tumoral PD-L1 expression are associated with depth of invasion in desmoplastic melanomas.

ABSTRACT:

Background

Desmoplastic melanoma (DM) is a rare subtype of spindle cell malignant melanoma characterized by frequent local recurrences and hematogenous spread, but without molecular classification. The aim of the study was to investigate in a DM series the incidence of relevant gene alterations in cancer, the programmed death-ligand 1 (PD-L1) expression status and the association with clinicopathological features and melanoma progression.

Methods

A total of 38 patients were included. Clinical follow-up and the histopathological features of all cases were retrospectively collected. PD-L1 expression by immunohistochemistry (IHC) and BRAF genomic alterations by real-time PCR were determined in 34 samples. Additionally, a molecular analysis by next-generation sequencing w

SUBMITTER: Alos L 

PROVIDER: S-EPMC7607103 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature