Mitotically associated long non-coding RNA is a tumor promoter in anaplastic thyroid cancer.

ABSTRACT:

Background

Patients with anaplastic thyroid cancer (ATC), which is among the deadliest of all cancers, often have a poor response to traditional therapies. Currently, the role of long non-coding RNAs (lncRNAs) in ATC carcinogenesis is unclear. In this study, we analyzed the lncRNA expression profile of ATC with the aim of identifying potential molecular targets for treatment of the disease.

Methods

Whole transcriptome sequencing of three ATC and two normal thyroid (NT) samples was performed, and the lncRNA expression profile of ATC was analyzed. Original data as well as datasets deposited in the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) were used for clinical validation. Cell proliferation, Transwell, and apoptosis assays were performed using ATC cell

SUBMITTER: Huang NS 

PROVIDER: S-EPMC7607122 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature