Identification and validation of novel DNA methylation markers for early diagnosis of lung adenocarcinoma.

ABSTRACT: Lung cancer has the highest mortality of all cancers worldwide. Epigenetic alterations have emerged as potential biomarkers for early diagnosis of various cancer tissue types. To identify methylation markers for early diagnosis of lung adenocarcinoma, we aimed to integrate genome-wide DNA methylation and gene expression data from The Cancer Genome Atlas. To this end, we first examined the global DNA methylation pattern of lung adenocarcinoma and investigated the relationship between DNA methylation subtypes and clinical features. We then extracted differentially methylated and expressed genes, and adopted feature selection techniques to determine the final methylation markers. The performance of the markers in predicting lung adenocarcinoma was evaluated on three independent datasets from

SUBMITTER: Li M 

PROVIDER: S-EPMC7607165 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature