Genomic profiling of newly diagnosed glioblastoma patients and its potential for clinical utility - a prospective, translational study.

ABSTRACT: Glioblastoma (GBM) is an incurable brain tumor for which new treatment strategies are urgently needed. Next-generation sequencing of GBM has most often been performed retrospectively and on archival tissue from both diagnostic and relapse surgeries with limited knowledge of clinical information, including treatment given. We sought to investigate the genomic composition prospectively in treatment-naïve patients, searched for possible targetable aberrations, and investigated for prognostic and/or predictive factors. A total of 108 newly diagnosed GBM patients were included. Clinical information, progression-free survival, and overall survival (OS) were noted. Tissues were analyzed by whole-exome sequencing, single nucleotide polymorphism (SNP) and transcriptome arrays, and RNA sequencing; a

SUBMITTER: Noroxe DS 

PROVIDER: S-EPMC7607169 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature