Differential Expression and Bioinformatic Analysis of the circRNA Expression in Migraine Patients.

ABSTRACT:

Background

CircRNAs are noncoding RNA molecules that have recently been described and shown to regulate miRNA functionality. While recent studies have suggested such circRNAs to be associated with pain related diseases in humans, no comprehensive migraine-related circRNA profiles have been generated, and there is currently no clear understanding of whether they can serve as regulators of migraine pathology.

Methods

We initially conducted a circRNA microarray analysis of the plasma of migraine patients and healthy controls. Based upon these data, we then selected 8 differentially expressed circRNAs and confirmed their expression in more migraine patient plasma samples via real-time PCR. We then performed functional and pathway enrichment analyses. Lastly, using a robust rank

SUBMITTER: Lin J 

PROVIDER: S-EPMC7607275 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature