Accelerated aging among childhood, adolescent, and young adult cancer survivors is evidenced by increased expression of p16^INK4a and frailty.

ABSTRACT:

Background

Cellular senescence, measured by expression of the cell cycle kinase inhibitor p16^INK4a , may contribute to accelerated aging in survivors of childhood, adolescent, and young adult cancer. The authors measured peripheral blood T-lymphocyte p16^INK4a expression among pediatric and young adult cancer survivors, hypothesizing that p16^INK4a expression is higher after chemotherapy and among frail survivors.

Methods

A cross-sectional cohort of young adult survivors and age-matched, cancer-free controls were assessed for p16^INK4a expression and frailty. Newly diagnosed pediatric patients underwent prospective measurements of p16^INK4a expression before and after cancer therapy. Frailty was measured with a modified Frie

SUBMITTER: Smitherman AB 

PROVIDER: S-EPMC7607511 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature