Pancreatic GLP-1r binding potential is reduced in insulin-resistant pigs.

ABSTRACT: The insulinotropic capacity of exogenous glucagon like peptide-1 (GLP-1) is reduced in type 2 diabetes and the insulin-resistant obese. We have tested the hypothesis that this response is the consequence of a reduced pancreatic GLP-1 receptor (GLP-1r) density in insulin-resistant obese animals. GLP-1r density was measured in lean and insulin-resistant adult miniature pigs after the administration of a 68Ga-labeled GLP-1r agonist. The effect of hyperinsulinemia on GLP-1r was assessed using sequential positron emission tomography (PET), both in the fasted state and during a clamp. The impact of tissue perfusion, which could account for changes in GLP-1r agonist uptake, was also investigated using 68Ga-DOTA imaging. GLP-1r binding potential in the obese pancreas was reduced by 75% compared wi

SUBMITTER: Malbert CH 

PROVIDER: S-EPMC7607594 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature