HbA1c during early pregnancy reflects beta-cell dysfunction in women developing GDM.

ABSTRACT:

Introduction

It is of current interest to assess eligibility of hemoglobin A1c (HbA1c) as a screening tool for earlier identification of women with risk for more severe hyperglycemia in pregnancy but data regarding accuracy are controversial. We aimed to evaluate if HbA1c mirrors pathophysiological precursors of glucose intolerance in early pregnancy that characterize women who develop gestational diabetes mellitus (GDM).

Research design and methods

220 pregnant women underwent an HbA1c measurement as well as an oral glucose tolerance test (OGTT) with multiple measurements of glucose, insulin and C-peptide for evaluation of insulin sensitivity and beta-cell function at 16th gestational week (IQR: 14-18). Clinical follow-ups were performed until end of pregnancy.

Results</

SUBMITTER: Bozkurt L 

PROVIDER: S-EPMC7607595 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature