A clear cancer cell line (150057) derived from human endometrial carcinoma harbors two novel mutations.

ABSTRACT:

Background

Cell lines are extremely useful for both basic and clinical research. Thus, establishing endometrial cancer cell lines with malignant histology is important. This study aimed to extensively characterize an endometrial clear cell carcinoma cell line.

Methods

This cell line, named 150,057, was derived from the endometrial clear cell cancer of a 63-year-old woman. The morphology, chromosomes, chemosensitivity, tumor markers, xenotransplantation characteristics, and cancer-related genes of the cell line were characterized.

Results

This cell line exhibited adequate growth, being passaged more than 70 times. The morphology of the cells was polygonal with a cobblestone-like appearance. Karyotyping of the cell line revealed a hypodiploid chromosomal number. 150057

SUBMITTER: Chang YH 

PROVIDER: S-EPMC7607743 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature