Gene Variants Associated With Venous Thrombosis: A Replication Study in a Brazilian Multicentre Study.

ABSTRACT: Single nucleotide polymorphisms (SNP) associated with Venous Thromboembolism (VTE) risk have been identified in European and American populations. Replicate SNPs associated with VTE in a Brazilian multicenter case-control study of the Southeast region. Patients with previous VTE assisted at the Outpatient Clinics of 3 centers of the Southeast Brazilian region were compared to normal controls of the same geographic region. We evaluated 29 SNPs associated with VTE risk in other populations, and 90 SNPs for stratification analysis of the population. Due to high admixture of Brazilian population and lack of previous studies, the calculation of the sample power was performed after genotyping. Sample size, allelic frequency and Hardy-Weinberg equilibrium were estimated. The association and odds

SUBMITTER: Romano AVC 

PROVIDER: S-EPMC7607786 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature