Associations of medications used during hospitalization and immunological changes in patients with COVID-19 during 3-month follow-up.

ABSTRACT:

Background

Understanding the immunological responses in COVID-19 patients during their recovery period is essential to the development of a vaccine and herd immunity.

Methods

This retrospective cohort study screened 233 patients admitted to the First Hospital of Changsha, China with COVID-19 from January 17th to February 29th, 2020. After completion of SARS-CoV2-specific immunoglobulins, and T cells tests at 2-week and 3-month follow-up points after discharge, 87 were enrolled. Wilcoxon signed-rank test was performed to assess changes in the values of IgG and IgM, the number of CD3+, CD4+ and CD8+ T cells, and CD4+/CD8+ ratio during the 3-month follow-up. Linear regressions were used to evaluate the associations of immunological changes and medications during hospitalization

SUBMITTER: Liu C 

PROVIDER: S-EPMC7608005 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature