A three-dimensional analysis of primary failure of eruption in humans and mice.

ABSTRACT:

Objectives

Primary failure of eruption (PFE) is a genetic disorder exhibiting the cessation of tooth eruption. Loss-of-function mutations in parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor (PTH/PTHrP receptor, PPR) were reported as the underlying cause of this disorder in humans. We showed in a PFE mouse model that PTHrP-PPR signaling is responsible for normal dental follicle cell differentiation and tooth eruption. However, the mechanism underlying the eruption defect in PFE remains undefined. In this descriptive study, we aim to chronologically observe tooth eruption and root formation of mouse PFE molars through 3D microCT analyses.

Setting and sample population

Two individuals with PFE were recruited at Showa University. A mouse PFE model w

SUBMITTER: Tokavanich N 

PROVIDER: S-EPMC7608053 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature