Gastrodin protects H9c2 cardiomyocytes against oxidative injury by ameliorating imbalanced mitochondrial dynamics and mitochondrial dysfunction.

ABSTRACT: Gastrodin (GAS) is the main bioactive component of Tianma, a traditional Chinese medicine widely used to treat neurological disorders as well as cardio- and cerebrovascular diseases. In the present study, the protective effects of GAS on H9c2 cells against ischemia-reperfusion (IR)-like injury were found to be related to decreasing of oxidative stress. Furthermore, GAS could protect H9c2 cells against oxidative injury induced by H₂O₂. Pretreatment of GAS at 20, 50, and 100 μM for 4 h significantly ameliorated the decrease in cell viability and increase in apoptosis of H9c2 cells treated with 400 μM H₂O₂ for 3 h. Furthermore, we showed that H₂O₂ treatment induced fragmentation of mitochondria and significant reduction in netw

SUBMITTER: Cheng QQ 

PROVIDER: S-EPMC7608121 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature