Elevated fatty acid amide hydrolase in the prefrontal cortex of borderline personality disorder: a [¹¹C]CURB positron emission tomography study.

ABSTRACT: Amygdala-prefrontal cortex (PFC) functional impairments have been linked to emotion dysregulation and aggression in borderline personality disorder (BPD). Fatty acid amide hydrolase (FAAH), the major catabolic enzyme for the endocannabinoid anandamide, has been proposed as a key regulator of the amygdala-PFC circuit that subserves emotion regulation. We tested the hypothesis that FAAH levels measured with [¹¹C]CURB positron emission tomography in amygdala and PFC would be elevated in BPD and would relate to hostility and aggression. Twenty BPD patients and 20 healthy controls underwent FAAH genotyping (rs324420) and scanning with [¹¹C]CURB. BPD patients were medication-free and were not experiencing a current major depressive episode. Regional differences in [^11<

SUBMITTER: Kolla NJ 

PROVIDER: S-EPMC7608329 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature