The exhaustive genomic scan approach, with an application to rare-variant association analysis.
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ABSTRACT:
SUBMITTER: Kanoungi G
PROVIDER: S-EPMC7608423 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
The exhaustive genomic scan approach, with an application to rare-variant association analysis.
Kanoungi George G Nothnagel Michael M Becker Tim T Drichel Dmitriy D
European journal of human genetics : EJHG 20200515 9
Region-based genome-wide scans are usually performed by use of a priori chosen analysis regions. Such an approach will likely miss the region comprising the strongest signal and, thus, may result in increased type II error rates and decreased power. Here, we propose a genomic exhaustive scan approach that analyzes all possible subsequences and does not rely on a prior definition of the analysis regions. As a prime instance, we present a computationally ultraefficient implementation using the rar ...[more]
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