Diverse and abundant resistome in terrestrial and aquatic vertebrates revealed by transcriptional analysis.

ABSTRACT: Despite increasing evidence that antibiotic resistant pathogens are shared among humans and animals, the diversity, abundance and patterns of spread of antibiotic resistance genes (ARGs) in wildlife remains unclear. We identified 194 ARGs associated with phenotypic resistance to 13 types of antibiotic in meta-transcriptomic data generated from a broad range of lower vertebrates residing in both terrestrial and aquatic habitats. These ARGs, confirmed by PCR, included those that shared high sequence similarity to clinical isolates of public health concern. Notably, the lower vertebrate resistome varied by ecological niche of the host sampled. The resistomes in marine fish shared high similarity and were characterized by very high abundance, distinct from that observed in other habitats. An a

SUBMITTER: Chen YM 

PROVIDER: S-EPMC7608656 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature