Resveratrol attenuates TLR-4 mediated inflammation and elicits therapeutic potential in models of sepsis.

ABSTRACT: Sepsis is a potentially fatal condition triggered by systemic inflammatory response to infection. Due to the heightened immune reactivity and multi-organ pathology, treatment options are limited and several clinical trials have not produced the desired outcome, hence the interest in the discovery of novel therapeutic strategies. The polyphenol resveratrol (RSV) has shown promise against several pathological states, including acute and chronic inflammation. In this study, we evaluated its therapeutic potential in a murine model of sepsis and in patients undergoing transrectal ultrasound biopsy. RSV was able to inhibit lipopolysaccharide (LPS) stimulated inflammatory responses through blocking Phospholipase D (PLD) and its downstream signaling molecules SphK1, ERK1/2 and NF-κB. In addition,

SUBMITTER: Wang B 

PROVIDER: S-EPMC7608666 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature