Breed Differences in Dog Cognition Associated with Brain-Expressed Genes and Neurological Functions.

ABSTRACT: Given their remarkable phenotypic diversity, dogs present a unique opportunity for investigating the genetic bases of cognitive and behavioral traits. Our previous work demonstrated that genetic relatedness among breeds accounts for a substantial portion of variation in dog cognition. Here, we investigated the genetic architecture of breed differences in cognition, seeking to identify genes that contribute to variation in cognitive phenotypes. To do so, we combined cognitive data from the citizen science project Dognition.com with published breed-average genetic polymorphism data, resulting in a dataset of 1654 individuals with cognitive phenotypes representing 49 breeds. We conducted a breed-average genome-wide association study to identify specific polymorphisms associated with breed dif

SUBMITTER: Gnanadesikan GE 

PROVIDER: S-EPMC7608742 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature