Development of an antigen detection assay for early point-of-care diagnosis of Zaire ebolavirus.

ABSTRACT: The 2013-2016 Ebola virus (EBOV) outbreak in West Africa and the ongoing cases in the Democratic Republic of the Congo have spurred development of a number of medical countermeasures, including rapid Ebola diagnostic tests. The likelihood of transmission increases as the disease progresses due to increasing viral load and potential for contact with others. Early diagnosis of EBOV is essential for halting spread of the disease. Polymerase chain reaction assays are the gold standard for diagnosing Ebola virus disease (EVD), however, they rely on infrastructure and trained personnel that are not available in most resource-limited settings. Rapid diagnostic tests that are capable of detecting virus with reliable sensitivity need to be made available for use in austere environments where labora

SUBMITTER: DeMers HL 

PROVIDER: S-EPMC7608863 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature