Lipocalin-2 Exacerbates Lupus Nephritis by Promoting Th1 Cell Differentiation.

ABSTRACT:

Background

Lipocalin-2 (LCN2) is an indicator of the severity of lupus nephritis (LN) and plays a pivotal role in immune responses, but it is not known if its effect on LN pathogenesis derives from regulating the immune imbalance of T lymphocyte subsets.

Methods

The expression of LCN2 in T cells and kidneys was assessed in renal biopsies from patients with LN. We investigated the relationship between LCN2 levels and development of LN and systemic illness by injecting anti-LCN2 antibodies into MRL/lpr mice and analyzing pristane-treated LCN2^-/- mice.

Results

LCN2 is highly expressed in CD4⁺ T cells and in renal tissues, and is associated with severe renal damage in patients with LN and in mice with experimental lupus. LCN2 pro

SUBMITTER: Chen W 

PROVIDER: S-EPMC7609012 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature