Ecotoxicity and genotoxicity assessment of losartan after UV/H₂O₂ and UVC/photolysis treatments.

ABSTRACT: Losartan potassium (LOS) is one of the most antihypertensives used in the world, and its presence in environmental matrices can cause impacts to biota. In this study, the ecotoxicity and genotoxicity of LOS was assessed before and after treatment by UVC/photolysis and UV/H₂O₂. The photodegradations were carried out at LOS solutions (2.5 mg L^-1; 4.6 μM) for 30, 60, 90, 120, 240, and 480 min of treatment. For chromatographic analysis, the samples were submitted to solid-phase extraction (SPE) and analyzed by HPLC-DAD. Ecotoxicity bioassays were conducted using Daphnia magna (acute) and Desmodesmus subspicatus (chronic) for all the degradation times. To evaluate the genotoxicity, the comet assay was performed with a D. magna whole organism cell suspension appl

SUBMITTER: Adams E 

PROVIDER: S-EPMC7609376 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature