Pcdh18a regulates endocytosis of E-cadherin during axial mesoderm development in zebrafish.

ABSTRACT: The notochord defines the axial structure of all vertebrates during development. Notogenesis is a result of major cell reorganization in the mesoderm, the convergence and the extension of the axial cells. However, it is currently not fully understood how these processes act together in a coordinated way during notochord formation. The prechordal plate is an actively migrating cell population in the central mesoderm anterior to the trailing notochordal plate cells. We show that prechordal plate cells express Protocadherin 18a (Pcdh18a), a member of the cadherin superfamily. We find that Pcdh18a-mediated recycling of E-cadherin adhesion complexes transforms prechordal plate cells into a cohesive and fast migrating cell group. In turn, the prechordal plate cells subsequently instruct the trai

SUBMITTER: Bosze B 

PROVIDER: S-EPMC7609436 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature