TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading.

ABSTRACT: Neurofibrillary tangles (NFTs) composed of hyperphosphorylated and misfolded tau protein are a pathological hallmark of Alzheimer's disease and other tauopathy conditions. Tau is predominantly an intraneuronal protein but is also secreted in physiological and pathological conditions. The extracellular tau has been implicated in the seeding and propagation of tau pathology and is the prime target of the current tau immunotherapy. However, truncated tau species lacking the microtubule-binding repeat (MTBR) domains essential for seeding have been shown to undergo active secretion and the mechanisms and functional consequences of the various extracellular tau are poorly understood. We report here that the transcription factor EB (TFEB), a master regulator of lysosomal biogenesis, plays an esse

SUBMITTER: Xu Y 

PROVIDER: S-EPMC7609570 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature