Genealogy of the neurodegenerative diseases based on a meta-analysis of age-stratified incidence data.

ABSTRACT: While the central common feature of the neurodegenerative diseases (NDs) is the accumulation of misfolded proteins, they share other pathogenic mechanisms. However, we miss an explanation for the onset of the NDs. The mechanisms through which genetic mutations, present from conception are expressed only after several decades of life are unknown. We aim to find clues on the complexity of the disease onset trigger of the different NDs expressed in the number of steps of factors related to a disease. We collected brain autopsies on diseased patients with NDs, and found a dynamic increase of the ND multimorbidity with the advance of age. Together with the observation that the NDs accumulate multiple misfolded proteins, and the same misfolded proteins are involved in more than one ND, motivated

SUBMITTER: Gerovska D 

PROVIDER: S-EPMC7609593 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature