Plasma P-Selectin Is Inversely Associated with Lung Function and Corticosteroid Responsiveness in Asthma.

ABSTRACT:

Background

Severe asthma has multiple phenotypes for which biomarkers are still being defined. Plasma P-selectin reports endothelial and/or platelet activation.

Objective

To determine if P-selectin is associated with features of asthma in a longitudinal study.

Methods

Plasmas from 70 adult patients enrolled in the Severe Asthma Research Program (SARP) III at the University of Wisconsin-Madison were analyzed for concentration of P-selectin at several points over the course of 3 years, namely, at baseline (BPS), after intramuscular triamcinolone acetonide (TA) injection, and at 36 months after baseline. Thirty-four participants also came in during acute exacerbation and 6 weeks after exacerbation.

Results

BPS correlated inversely with forced expiratory volume in

SUBMITTER: Johansson MW 

PROVIDER: S-EPMC7609594 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature