Relationship between neural functional connectivity and memory performance in age-related macular degeneration.

ABSTRACT: Age-related macular degeneration (AMD) has been linked to memory deficits, with no established neural mechanisms. We collected resting-state brain functional magnetic resonance imaging and standardized verbal recall tests from 42 older adults with AMD and 41 age-matched controls. We used seed-based whole brain analysis to quantify the strength of functional connectivity between hubs of the default mode network and a network of medial temporal regions relevant for memory. Our results indicated neither memory performance nor network connectivity differed by AMD status. However, the AMD participants exhibited stronger relationships than the controls between memory performance and connectivity from the memory network hub (left parahippocampal) to 2 other regions: the left temporal pole and the

SUBMITTER: Zuo X 

PROVIDER: S-EPMC7609595 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature